The safe contains Raw Whale Bone, Rune, and lot of money. For example, if it said remember Lying Tongue, Wanton Flesh, and Restless Hands, the code would be 2, 6, 3. Use the numbers from the Seven Strictures that were on the first note.

Go back to the safe and check the book on the bench to the right. It will tell you to remember three specific things. Go to the room nearby with a projector inside and grab the note off the table. Safe Location 2: There is a safe inside the Vice Overseers Office in the Karnaca Enclave. The safe contains two Silver Bars and some bullets. The clue can be found behind the painting in the room. Inside is the safe, and the code for it is ' 451'.

Search the door to the left of that one (as you look at it) for another door.

Safe Location 1: When you exit the palace and are on the Dunwall streets, progress until you see a large 'For Rent' sign on a house to the left. Search the indicated locations to find the safes and codes to unlock the safes to obtain the corresponding loot: Stack five Void Favor Charms (four traits) to get unlimited mana. Sacrificing the Bonecharm will not give you any additional Whalebones it will just re-appear. Kill him, then you should be able to loot him again for the same charm. Loot his body for three Bonecharms, but make sure to sacrifice the third Bonecharm. This may also work on Breanna in Mission 5. In Mission 6: The Dust District, knockout Paolo. It can cause weird visual effects at your start and save screens. Note: Create a backup save before using this exploit, as it could cause issues with your game.

Dishonored 2 mission 7 runes